INSERM U872 - Nutriomique. Nutrition obésité : approche génétique et transcriptomique

2002

1. Clement K, Vega N, Laville M, Pelloux V, Guy-Grand B, Basdevant A, Vidal H. Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor. Int J Obes Relat Metab Disord. 2002 Dec;26(12):1533-8.

2. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 2002;11(21):2607-14.

3. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS. Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med. 2002;8(7):643-4.

4. Barat-Houari M, Clement K, Vatin V, Dina C, Bonhomme G, Vasseur F, Guy-Grand B, Froguel P. Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. Diabetes. 2002;51(5):1640-3.

5. Delplanque J, Vasseur F, Durand E, Abderrahmani A, Dina C, Waeber G, Guy-Grand B, Clement K, Weill J, Boutin P, Froguel P. Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. J Clin Endocrinol Metab. 2002;87(2):867-9.

6. Clement K, Viguerie N, Diehn M, Alizadeh A, Barbe P, Thalamas C, Storey JD, Brown PO, Barsh GS, Langin D. In vivo regulation of human skeletal muscle gene expression by thyroid hormone. Genome Res. 2002;12(2):281-91.

7. Saves M, Raffi F, Capeau J, Rozenbaum W, Ragnaud JM, Perronne C, Basdevant A, Leport C, Chene G; Antiproteases Cohorte (APROCO) Study Group. Factors related to lipodystrophy and metabolic alterations in patients with human immunodeficiency virus infection receiving highly active antiretroviral therapy. Clin Infect Dis. 2002;34(10):1396-405.

8. Hazan U, Romero IA, Cancello R, Valente S, Perrin V, Mariot V, Dumonceaux J, Gerhardt CC, Strosberg AD, Couraud PO, Pietri-Rouxel F. Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1? FASEB J. 2002 Aug;16(10):1254-6. Epub 2002 Jun 21. Erratum in: FASEB J 2002 Oct;16(12):4.

9. Cinti S, Cancello R, Zingaretti MC, Ceresi E, De Matteis R, Giordano A, Himms-Hagen J, Ricquier D. CL316,243 and cold stress induce heterogeneous expression of UCP1 mRNA and protein in rodent brown adipocytes. J Histochem Cytochem. 2002;50(1):21-31.

10. Aggoun Y, Tounian P, Dabbas-Tyan M, Massih TA, Girardet JP, Ricour C, Sidi D, Bonnet D. Arterial rigidity and endothelial dysfunction in obese children. Arch Mal Coeur Vaiss. 2002 Jul-Aug;95(7-8):631-5.

11. Ribière C, Jaubert Am, Sabourault D, Lacasa D, Giudicelli Y. Insulin stimulates nitric oxide production in rat adipocytes. Biochim.Biophys. Res. Commun. 2002;291:394-399.

12. Garcia Dos Santos E, Dieudonnè Mn, Pecquery R, Lemoal V, Giudicelli Y, Lacasa D. Rapid non genomic E2 effects on p42/p44 MAPK, activator protein-1 and cAMP response element binding protein in rat white adipocytes. Endocrinology 2002;143:930-940.

13. Clement L, Poirier H, Niot I, Bocher V, Guerre-Millo M, Krief S, Staels B, Besnard P. Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res. 2002 Sep;43(9):1400-9.

14. Grosfeld A, Andre J, Hauguel-De Mouzon S, Berra E, Pouyssegur J, Guerre-Millo M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem. 2002;277(45):42953-7.

15. Peyron-Caso E, Fluteau-Nadler S, Kabir M, Guerre-Millo M, Quignard-Boulange A, Slama G, Rizkalla SW. Regulation of glucose transport and transporter 4 (GLUT-4) in muscle and adipocytes of sucrose-fed rats: effects of N-3 poly- and monounsaturated fatty acids. Horm Metab Res. 2002;34(7):360-6.

16. Peyron-Caso E, Taverna M, Guerre-Millo M, Veronese A, Pacher N, Slama G, Rizkalla SW. Dietary (n-3) polyunsaturated fatty acids up-regulate plasma leptin in insulin-resistant rats. J Nutr. 2002;132(8):2235-40.

17. Grosfeld A, Zilberfarb V, Turban S, Andre J, Guerre-Millo M, Issad T. Hypoxia increases leptin expression in human PAZ6 adipose cells. Diabetologia. 2002;45(4):527-30.

18. Madsen L, Guerre-Millo M, Flindt EN, Berge K, Tronstad KJ, Bergene E, Sebokova E, Rustan AC, Jensen J, Mandrup S, Kristiansen K, Klimes I, Staels B, Berge RK. Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. J Lipid Res. 2002;43(5):742-50.

19. Turban S, Hainault I, Truccolo J, Andre J, Ferre P, Quignard-Boulange A, Guerre-Millo M. Specific increase in leptin production in obese (falfa) rat adipose cells. Biochem J. 2002;362(Pt 1):113-8.

20. Duplus E, Glorian M, Tordjman J, Berge R, Forest C. Evidence for selective induction of phosphoenolpyruvate carboxykinase gene expression by polyunsaturated and nonmetabolized fatty acids in adipocytes. J. Cell. Biochem. 2002;85:651-661.

21. Kabir M., Oppert J.M., Vidal H., Bruzzo F., Fiquet C., Wursch P., Slama G., Rizkalla S.W Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. Metabolism. 2002 Jul;51(7):819-26

22. Rizkalla S.W., Jing-Luo J., Wills D., Bruzzo F., Slama G., Glycaemic and insulinaemic responses to a -Lycasin HBC maltitol syrup in Healthy and Type 2 diabetic subjetc, Diabetes & metabolism 2002, 28: 385-90

23. Rizkalla S.W., Bellisle F., Slama G., Benefits of low glycemic index foods, such as pulses, in diabetic patients and healthy individuals, British J. Nutr. 2002; 88, Suppl3: 255-262

24. Peyron-Caso E., Fluteau S., Taverna M., Guerre-Millo M., Chevalier A., Pacher N., G Slama, Rizkalla S.W., Dietary (n-3) polyunsaturated fatty acids up-regulate plasma leptin in insulin-resistant rats J Nutr 2002, Aug;132(8):2235-40

25. Bournaud I, Courtine M, Zucker JD (2002). Propositionalization for Clustering Symbolic Relational Descriptions. International Conference on Inductive Logic Programming, Sydney, Aus., Springer Verlag.

26. Breton L, Claudin P, Clément E, Zucker JD (2002). "Stress Response Function to a two-dimensional ordered packing of frictional beads." Europhysics Letter.

27. Bouché, C., Rizkalla, S.W., Luo, J., Vidal, H., Veronese, A., Pacher N, Fouquet, C., Lang V, Slama G. Five week low-glyczmic idex diet decreases total fat mass and improves plasma lipid profile in moderately overweight non diabetic subjects. Diabetes Care 2002, 25: 822-828

2003

28. Boutin P, Dina C, Vasseur F, Dubois S S, Corset L, Seron K, Bekris L, Cabellon J, Neve B, Vasseur-Delannoy V, Chikri M, Charles MA, Clement K, Lernmark A, Froguel P. GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity. PLoS Biol. 2003;1(3):E68.

29. Franca S, Marchand C, Craplet C, Basdevant A, d'Ivernois JF. Application of "Concept Mapping" in obese subjects: a pilot study in normo and underreporters. Diabetes Metab. 2003;29(1):72-8.

30. Liu YM, Lacorte JM, Viguerie N, Poitou C, Pelloux V, Guy-Grand B, Coussieu C, Langin D, Basdevant A, Clement K. Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding. J Clin Endocrinol Metab. 2003;88(12):5881-6.

31. Coudreau S, Tounian P, Bonhomme G, Froguel P, Girardet JP, Guy-Grand B, Basdevant A, Clement K. Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. Obes Res. 2003;11(10):1163-7.

32. Rome S, Clement K, Rabasa-Lhoret R, Loizon E, Poitou C, Barsh GS, Riou JP, Laville M, Vidal H. Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. J Biol Chem. 2003;278(20):18063-8.

33. Boute N, Boubekeur S, Lacasa D, Issad T. Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells. EMBO Reports 2003;4:313-319.

34. Lepercq J, Guerre-Millo M, Andre J, Cauzac M, Hauguel-de Mouzon S. Leptin: a potential marker of placental insufficiency. Gynecol Obstet Invest. 2003;55(3):151-5.

35. Gilbert M, Magnan C, Turban S, Andre J, Guerre-Millo M. Leptin receptor-deficient obese Zucker rats reduce their food intake in response to a systemic supply of calories from glucose. Diabetes. 2003;52(2):277-82.

36. Tordjman J, Chauvet G, Quette J, Beale EG, Forest C, Antoine B. Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells. J. Biol. Chem. 2003;278:18785-18790.

37. Tordjman J, Khazen W, Antoine B, Chauvet G, Quette J, Fouque F, Beale EG, Benelli C, Forest C. Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes. Biochimie. 2003; 85:1213-1218.

38. Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet 2003;12(2): 145-153.

39. Lubrano-Berthelier C, Cavazos M, Le Stunff C, Hass K, Shapiro A, Zhang S, Bougnères P, Vaisse C. The human MC4R promoter: characterization and role in obesity. Diabetes 2003;52:2996-3000.

40. Peyron-Caso E, Quignard-Boulangé A, Laromiguière M, Feing-Kwong-Chan S, Véronèse A, Ardouin B, Slama G, Rizkalla SW. Dietary Fish Oil Increased Lipid Mobilization but Could Not Decreased Lipid Storage Related Enzyme Activities in Adipose Tissue of Insulin-Resistant Sucrose-fed Rats. J Nutr 2003, 133:2239-2243.

41. Hanczar B, Courtine M, Benis A, Henegar C, Clément K, Zucker JD. Improving classification of microarray data using prototype based feature selection ACM SIGKDD Explorations, Special issue on micro-array, 2003;(5)2:21-28.

42. Houdouin L, Polivka M, Henegar C, Blanquet A, Delalande O, Mikol J (2003). Pituitary germinoma and lymphocytic hypophysitis : a pitfall. Report of two cases. Annales de Pathologie. 23(4) :349-54.

2004

43. Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, CuratCA, Sicard A, Rome S, Benis A, Zucker JD, Vidal H, Laville M, Barsh GS, Basdevant A, Stich V, Cancello R, Langin D. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J, 2004 Nov; 18(14):1657-69.

44. Bellisle F, Clement K, Le Barzic M, Le Gall A, Guy-Grand B, Basdevant A. The Eating Inventory and body adiposity from leanness to massive obesity: a study of 2509 adults. Obes Res. 2004 Dec; 12(12):2023-30

45. Cécile Lubrano-Berthelier, Supriya Srinivasan, Cedric Govaerts, Franck Picard, Pamela Santiago, Astrid Shapiro, Bruce R. Conklinand Christian Vaisse. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest, 2004 (sous presse)

46. Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P. Polymorphisms in the amino Acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Diabetes. 2004;53(9):2483-6.

47. Eberle D, Clement K, Meyre D, Sahbatou M, Vaxillaire M, Le Gall A, Ferre P, Basdevant A, Froguel P, Foufelle F. SREBP-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes. 2004; 53(8):2153-7.

48. Kipfer-Coudreau S, Eberle D, Sahbatou M, Bonhomme A, Guy-Grand B, Froguel P, Galan P, Basdevant A, Clement K. Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects. Diabetologia. 2004;47(7):1278-84.

49. Bell CG, Benzinou M, Siddiq A, Lecoeur C, Dina C, Lemainque A, Clement K, Basdevant A, Guy-Grand B, Mein CA, Meyre D, Froguel P. Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. Diabetes. 2004;53(7):1857-65.

50. Liu YM, Moldes M, Bastard JP, Bruckert E, Viguerie N, Hainque B, Basdevant A, Langin D, Pairault J, Clement K. Adiponutrin: A new gene regulated by energy balance in human adipose tissue. J Clin Endocrinol Metab. 2004;89(6):2684-9.

51. Viguerie N, Clement K, Barbe P, Courtine M, Benis A, Larrouy D, Hanczar B, Pelloux V, Poitou C, Khalfallah Y, Barsh GS, Thalamas C, Zucker JD, Langin D. In vivo epinephrine-mediated regulation of gene expression in human skeletal muscle. J Clin Endocrinol Metab. 2004;89(5):2000-14.

52. Prat-Larquemin L, Oppert JM, Clement K, Hainault I, Basdevant A, Guy-Grand B, Quignard-Boulange A. Adipose angiotensinogen secretion, blood pressure, and AGT M235T polymorphism in obese patients. Obes Res. 2004 Mar;12(3):556-61.

53. Borgnon J, Tounian P, Auber F, Larroquet M, Boeris Clemen F, Girardet JP, Audry G. Esophageal replacement in children by an isoperistaltic gastric tube: a 12-year experience. Pediatr Surg Int. 2004 Jul 9.

54. Lubrano-Berthelier C, Le Stunff C, Bougneres P, Vaisse C. A Homozygous Null Mutation Delineates The Role Of The Melanocortin-4 Receptor In Humans. JCEM 2004;89:2028-2032.

55. Garaulet M, Viguerie N, Porubsky S, Klimcakova E, Clement K, Langin D, Stich V. Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance. J Clin Endocrinol Metab. 2004;89(2):756-60.

56. Mann J, De Leeuw I, Harmensen k, Karamanos B, Karlstrom B, Katsilambros N, Riccardi G, Rivillese A A, Rizkalla SW, Slama G , Toeller M, Uusitupa M, Vessby B. Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutrition, Metabolism and Cardiovascular Disease 2004, 14, 373-394.

57. , Laika T ,Laromiguiere M, Huet D, Boillot J, Rigoir A, Slama G. Improved plasma glucose control, whole body glucose utilization and lipid profile on a low glycemic index diet in type 2 diabetic men: A randomized-controlled trial . Diabetes Care 2004, 27:1866-72

58. Broca C, Breil V, Cruciani-Guglielmacci C, Manteghetti M, Rouault C, Derouet M, Rizkalla S, Pau B, Petit P, Ribes G, Ktorza A, Gross R, Reach G, and Taouis M^.The insulinotropic agent ID1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am J Physiol Endocrinol Metab 2004, 287:E463-471

59. Blacher J, Czernichow S, Henegar C, Leroux P, Moreau I, Roux O, Safar M (2004). Paramètres tensionels, risque cardiovasculaire, objectifs et béné_ces thérapeutiques dans l'hypertension artérielle. Journ Annu Diabetol Hotel Dieu. 2004 ; :195-202.

60. Georges C, Chassany O, Mouthon L, Tiev K, Toledano C, Meyer O, Marjanovic Z, Henegar C, Papo T, Crickx B, Sereni D, Cabane J, Farge D (2004). Validation of French version of the Scleroderma Health Assessment Questionnaire (SSc HAQ). Clin Rheumatol. 2004 Jun 23.

61. Georges C, Toledano C, Zagdanski AM, Henegar C, Bourgarit A, Sereni D, Farge D (2004). Thoracic disk herniation mimicking renal crisis. Eur J Intern Med. 2004 Feb ;15(1) :59-61.

62. Henegar C, Bousquet C, Lillo-Le Louet A, Degoulet P, Jaulent M. A knowledge based approach for automated signal generation in pharmacovigilance. Medinfo 2004;2004:626-30.

63. Zucker JD. A grounded theory of abstraction in artificial intelligence. Philos Trans R Soc Lond B Biol Sci. 2003;358(1435):1293-309.

64. Bredèche N, Chevaleyre Y, Zucker JD, Drogoul A, Sabah G. (2003). "A meta-learning approach to anchor visual percepts." Robotics and Autonomous System Journal (special issue on Anchoring Symbols to Sensor Data in Single and Multiple Robot Systems.).

65. Courtine M, Clement K, Zucker JD. Exploratory characterization of coexpressed genes by conceptual clustering of their associated GO annotations: the MaGO system. 6th International Meeting of the Microarray Gene Expression 2003. Data Society, MGED'2003, Aix-en-Provence.

2005

66. Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C, Coupaye M, Pelloux V, Hugol D, Bouillot JL, Bouloumie A, Barbatelli G, Cinti S, Svensson PA, Barsh GS, Zucker JD, Basdevant A, Langin D, Clement K. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005 54(8):2277-86

67. Poitou C, Lacorte JM, Coupaye M, Bertrais S, Bedel JF, Lafon N, Bouillot JL, Galan P, Borson-Chazot F, Basdevant A, Coussieu C, Clement K. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg. 2005 Jan;15(1):11-23.

68. Taleb S, Lacasa D, Bastard JP, Poitou C, Cancello R, Pelloux V, Viguerie N, Benis A, Zucker JD, Bouillot JL, Coussieu C, Basdevant A, Langin D, Clement K. Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis. FASEB J. 2005 Sep;19(11):1540-2. Epub 2005 Jun 28.

69. Poitou C, Viguerie N, Cancello R, De Matteis R, Cinti S, Stich V, Coussieu C, Gauthier E, Courtine M, Zucker JD, Barsh GS, Saris W, Bruneval P, Basdevant A, Langin D, Clement K. Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Diabetologia. 2005 Mar;48(3):519-28. Epub 2005 Feb 24.

70. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005 Mar 24;434(7032):514-20. Epub 2005 Feb 20.

71. Svegliati S, Cancello R, Sambo P, Luchetti M, Paroncini P, Orlandini G, Discepoli G, Paterno R, Santillo M, Cuozzo C, Cassano S, Avvedimento EV, Gabrielli A. “Platelet-derived Growth Factor and Reactive Oxygen Species (ROS) Regulate Ras Protein Levels in Primary Human Fibroblasts via ERK1/2: AMPLIFICATION OF ROS AND Ras IN SYSTEMIC SCLEROSIS FIBROBLASTS.” J Biol Chem. 2005 Oct 28;280(43):36474-82.

72. Cancello R, Piétri-Rouxel F, Clément K, "Spontaneous lipid accumulation in primary cultures of dedifferentiated human adipocytes ", Adipocytes, Vol.1, No.1, pp.73-78, 2005 (nouveau journal)

73. Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clement K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet. 2005 Aug ;37(8):863-7. Epub 2005 Jul 17.

74. Lacasa D, Boute N, Issad T. Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPalpha and PTPepsilon in living cells. Mol Pharmacol. 2005 Apr;67(4):1206-13.

75. Blanquart C, Boute N, Lacasa D, Issad T. Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer. Mol Pharmacol. 2005 Sep;68(3):885-94

76. Perlemuter G, Davit-Spraul A, Cosson C, Conti M, Bigorgne A, Paradis V, Corre MP, Prat L, Kuoch V, Basdevant A, Pelletier G, Oppert JM, Buffet C. Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease. Liver Int. 2005 Oct;25(5):946-53.

77. Coupaye M, Bouillot JL, Coussieu C, Guy-Grand B, Basdevant A, Oppert JM. One-year changes in energy expenditure and serum leptin following adjustable gastric banding in obese women. Obes Surg. 2005 Jun-Jul;15(6):827-33.

78. Bocquier A, Verger P, Basdevant A, Andreotti G, Baretge J, Villani P, Paraponaris A. Overweight and obesity: knowledge, attitudes, and practices of general practitioners in france. Obes Res. 2005 Apr;13(4):787-95.

79. Simler N, Grosfeld A, Peinnequin A, Guerre-Millo M, Bigard AX. Leptin receptor deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia. Am J Physiol Endocrinol Metab. 2005 [Epub ahead of print].

80. Poirier H, Rouault C, Clement L, Niot I, Monnot MC, Guerre-Millo M, Besnard P. Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Diabetologia. 2005 48:1059-65.

81. Bihan H, Rouault C, Reach G, Poitout V, Staels B, Guerre-Millo M. Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha). FEBS Lett. 2005 579:2284-8.

82. Yvan-Charvet L, Even P, Bloch-Faure M, Guerre-Millo M, Moustaid-Moussa N, Ferre P, Quignard-Boulange A. Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Diabetes. 2005 54:991-9.

83. Guerin F, Henegar C, Spiridon G, Launay O, Salmon-Ceron D, Poyart C. Bacterial prostatitis due to Pseudomonas aeruginosa harbouring the blaVIM-2 metallo-{beta}-lactamase gene from Saudi Arabia. J Antimicrob Chemother. 2005 Sep ;56(3) :601-2.

84. Farge D, Henegar C, Carmagnat M, Daneshpouy M, Marjanovic Z, Rabian C, Ilie D, Douay C, Mounier N, Clave E, Bengoufa D, Cabane J, Marolleau JP, Gluckman E, Charron D, Toubert A. Analysis of immune reconstitution after autologous bone marrow transplantation in systemic sclerosis. Arthritis Rheum. 2005 ; 52(5) :1555-63.

85. Toledano C, Henegar C, Ilie D, Launay D, Tiev K, Marie I, Marjanovic Z, Emmerich J, Cabane J, Menasche S, Farge D. Cardiopulmonary function before and after cyclophosphamide treatment in severe systemic sclerosis : comparison of monthly intravenous bolus and autologous haematopoietic stem cell transplantation. Rev Med Interne. 2005 ; 26(6) :444-52.

86. Wermter AK, Reichwald K, Buch T, Geller F, Platzer C, Huse K, Hess C, Remschmidt H, Gudermann T, Preibisch G, Siegfried W, Goldschmidt HP, Li WD, Price RA, Biebermann H, Krude H, Vollmert C, Wichmann HE, Illig T, Sorensen TI, Astrup A, Larsen LH, Pedersen O, Eberle D, Clement K, Blundell J, Wabitsch M, Schafer H, Platzer M, Hinney A, Hebebrand J. Mutation analysis of the MCHR1 gene in human obesity. Eur J Endocrinol. 2005 Jun;152(6):851-62.

87. Vasseur F, Helbecque N, Lobbens S, Vasseur-Delannoy V, Dina C, Clement K, Boutin P, Kadowaki T, Scherer PE, Froguel P. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia. 2005 May;48(5):892-9. Epub 2005 Apr 14.

88. Guerardel A, Barat-Houari M, Vasseur F, Dina C, Vatin V, Clement K, Eberle D, Vasseur-Delannoy V, Bell CG, Galan P, Hercberg S, Helbecque N, Potoczna N, Horber FF, Boutin P, Froguel P. Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genet. 2005 Apr 11;6(1):19.

89. Ghoussaini M, Meyre D, Lobbens S, Charpentier G, Clement K, Charles MA, Tauber M, Weill J, Froguel P. Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC Med Genet. 2005 Mar 22;6:11.

90. Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clement K, Galan P, Hercberg S, Helbecque N, Charpentier G, Prentki M, Hansen T, Pedersen O, Urrutia R, Melloul D, Froguel P. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4807-12.

91. Rossi AS, Lombardo YB,.Lacorte JM, Chicco AG, Rouault C, Slama G and Rizkalla SW Dietary fish oil regulates positively plasma leptin and adiponectin levels in sucrose fed insulin resistant rats. Am J physiol 2005, 289: p. R486-R494

92. Henegar C, Bousquet C, Lillo-Le Louet A, Degoulet P, Jaulent MC. Building an ontology of adverse drug reactions for automated signal generation in pharmacovigilance. Comput Biol Med 2005 Sep.

93. Bousquet C, Henegar C, Louet AL, Degoulet P, Jaulent MC. Implementation of automated signal generation in pharmacovigilance using a knowledge-based approach. Int J Med Inform. 2005; 74(7-8) :563-71.

2006

94. Santos JL, Boutin P, Verdich C, Holst C, Larsen LH, Toubro S, Dina C, Saris WH, Blaak EE, Hoffstedt J, Taylor MA, Polak J, Clement K, Langin D, Astrup A, Froguel P, Pedersen O, Sorensen TI, Martinez JA; NUGENOB* consortium. Genotype-by-nutrient interactions assessed in European obese women. A case-only study. Eur J Nutr. 2006 Dec;45(8):454-62. Epub 2006 Nov 1. PubMed PMID: 17080261.

95. Cancello R, Taleb S, Poitou C, Tordjman J, Lacasa D, Guerre-Millo M, Clément K. [Is obesity an inflammatory disease?]. Journ Annu Diabetol Hotel Dieu.2006:115-28. Review. French. PubMed PMID: 17051855.

96. Mutch DM, Clément K. Unraveling the genetics of human obesity. PLoS Genet. 2006 Dec 29;2(12):e188. Review. PubMed PMID: 17196040; PubMed Central PMCID: PMC1756898.

97. Mutch DM, Clément K. Genetics of human obesity. Best Pract Res Clin Endocrinol Metab. 2006 Dec;20(4):647-64. Review. PubMed PMID: 17161337.

98. Clément K. [Human obesity: toward functional genomics]. J Soc Biol. 2006;200(1):17-28. Review. French. PubMed PMID: 17144158.

99. Poitou C, Coupaye M, Laaban JP, Coussieu C, Bedel JF, Bouillot JL, Basdevant A, Clément K, Oppert JM. Serum amyloid A and obstructive sleep apnea syndrome before and after surgically-induced weight loss in morbidly obese subjects. Obes Surg. 2006 Nov;16(11):1475-81. PubMed PMID: 17132414.

100. Taleb S, Cancello R, Poitou C, Rouault C, Sellam P, Levy P, Bouillot JL, Coussieu C, Basdevant A, Guerre-Millo M, Lacasa D, Clement K. Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women. J Clin Endocrinol Metab. 2006 Mar;91(3):1042-7. Epub 2006 Jan 4. PubMed PMID:16394095.

101. Taleb S, Van Haaften R, Henegar C, Hukshorn C, Cancello R, Pelloux V, Hanczar B, Viguerie N, Langin D, Evelo C, Zucker J, Clément K, Saris WH. Microarray profiling of human white adipose tissue after exogenous leptin injection. Eur J Clin Invest. 2006 Mar;36(3):153-63. PubMed PMID: 16506959.

102. Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab. 2006 May;91(5):1811-8. Epub 2006 Feb 28. PubMed PMID: 16507637.

103. Poitou C, Coussieu C, Rouault C, Coupaye M, Cancello R, Bedel JF, Gouillon M, Bouillot JL, Oppert JM, Basdevant A, Clément K. Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status. Obesity (Silver Spring). 2006 Feb;14(2):309-18. PubMed PMID: 16571858.

104. Ahn JD, Dubern B, Lubrano-Berthelier C, Clement K, Karsenty G. Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency. Endocrinology. 2006 Jul;147(7):3196-202. Epub 2006 Apr 13. PubMed PMID: 16614075.

105. Clément K. Mutation in the MC4R gene promoter: an elusive or effective role? Horm Res. 2006;66(2):70-2. Epub 2006 May 19. PubMed PMID: 16710098.

106. Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D, Coussieu C, Basdevant A, Bar Hen A, Bedossa P, Guerre-Millo M, Clément K. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes. 2006 Jun;55(6):1554-61. PubMed PMID: 16731817.

107. Kim MJ, Maachi M, Debard C, Loizon E, Clément K, Bruckert E, Hainque B, Capeau J, Vidal H, Bastard JP. Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss. Eur J Endocrinol. 2006 Jul;155(1):161-5. PubMed PMID: 16793963.

108. Taleb S, Cancello R, Clément K, Lacasa D. Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation. Endocrinology. 2006 Oct;147(10):4950-9. Epub 2006 Jul 6. PubMed PMID: 16825321.

109. Clément K. Genetics of human obesity. C R Biol. 2006 Aug;329(8):608-22; discussion 653-5. Epub 2006 May 15. Review. PubMed PMID: 16860279.

110. Sørensen TI, Boutin P, Taylor MA, Larsen LH, Verdich C, Petersen L, Holst C, Echwald SM, Dina C, Toubro S, Petersen M, Polak J, Clément K, Martínez JA, Langin D, Oppert JM, Stich V, Macdonald I, Arner P, Saris WH, Pedersen O, Astrup A, Froguel P; NUGENOB Consortium. Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. PLoS Clin Trials. 2006 Jun;1(2):e12. Epub 2006 Jun 30. PubMed PMID: 16871334; PubMed Central PMCID: PMC1488899.

111. Cancello R, Clément K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG. 2006 Oct;113(10):1141-7. Epub 2006 Aug 10. Review. PubMed PMID: 16903845.

112. Moldes M, Beauregard G, Faraj M, Peretti N, Ducluzeau PH, Laville M, Rabasa-Lhoret R, Vidal H, Clément K. Adiponutrin gene is regulated by insulin and glucose in human adipose tissue. Eur J Endocrinol. 2006 Sep;155(3):461-8. PubMed PMID: 16914601.

113. Henegar C, Cancello R, Rome S, Vidal H, Clément K, Zucker JD. Clustering biological annotations and gene expression data to identify putatively co-regulated biological processes. J Bioinform Comput Biol. 2006 Aug;4(4):833-52. PubMed PMID: 17007070.

2007

114. Mutch DM, Temanni MR, Henegar C, Combes F, Pelloux V, Holst C, Sørensen TI, Astrup A, Martinez JA, Saris WH, Viguerie N, Langin D, Zucker JD, Clément K. Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders. PLoS One. 2007 Dec 19;2(12):e1344. PubMed PMID: 18094752; PubMed Central PMCID: PMC2147074.

115. Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulangé A, Vidal H, Slama G, Clément K, Guerre-Millo M, Rizkalla SW. Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr. 2007 Dec;86(6):1670-9. PubMed PMID: 18065585.

116. Silaghi A, Achard V, Paulmyer-Lacroix O, Scridon T, Tassistro V, Duncea I, Clément K, Dutour A, Grino M. Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1443-50. Epub 2007 Sep 18. PubMed PMID: 17878224.

117. Clement K, Langin D. Regulation of inflammation-related genes in human adipose tissue. J Intern Med. 2007 Oct;262(4):422-30. Review. PubMed PMID: 17875178.

118. Taleb S, Herbin O, Ait-Oufella H, Verreth W, Gourdy P, Barateau V, Merval R, Esposito B, Clément K, Holvoet P, Tedgui A, Mallat Z. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2691-8. Epub 2007 Aug 9. PubMed PMID: 17690315.

119. Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clément K, Langin D. The transcriptional coactivator peroxisome proliferators activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes. Diabetes. 2007 Oct;56(10):2467-75. Epub 2007 Jul 23. PubMed PMID: 17646210.

120. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug;9(8):970-7. Epub 2007 Jul 22. PubMed PMID: 17643114.

121. Dubern B, Bisbis S, Talbaoui H, Le Beyec J, Tounian P, Lacorte JM, Clément K. Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesity. J Pediatr. 2007 Jun;150(6):613-7, 617.e1. PubMed PMID: 17517245.

122. Dubern B, Clément K. [Genetic aspects of obesity]. Presse Med. 2007 Nov;36(11 Pt 2):1598-605. Epub 2007 May 21. Review. French. PubMed PMID: 17513079.

123. Taleb S, Clément K. Emerging role of cathepsin S in obesity and its associated diseases. Clin Chem Lab Med. 2007;45(3):328-32. Review. PubMed PMID: 17378727.

124. Meugnier E, Faraj M, Rome S, Beauregard G, Michaut A, Pelloux V, Chiasson JL, Laville M, Clement K, Vidal H, Rabasa-Lhoret R. Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects. Diabetes. 2007 Apr;56(4):992-9. Epub 2007 Feb 15. PubMed PMID: 17303805.

125. Faraj M, Beauregard G, Loizon E, Moldes M, Clément K, Tahiri Y, Cianflone K, Vidal H, Rabasa-Lhoret R. Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrin. J Endocrinol. 2006 Nov;191(2):427-35. Erratum in: J Endocrinol. 2007 Jan;192(1):269. PubMed PMID: 17088412.

126. Lacasa D, Taleb S, Keophiphath M, Miranville A, Clement K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology. 2007 Feb;148(2):868-77. Epub 2006 Nov 2. PubMed PMID: 17082259.

2008

127. Tordjman J, Guerre-Millo M, Clément K. Adipose tissue inflammation and liver pathology in human obesity. Diabetes Metab. 2008 Dec;34(6 Pt 2):658-63. Review. PubMed PMID: 19195627.

128. Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi MA, Darakhshan F, Guerre-Millo M, Clement K, Gelb BD, Dolgnov G, Shi GP. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2202-8. Epub 2008 Sep 25. PubMed PMID: 18818416; PubMed Central PMCID: PMC2736686.

129. Prifti E, Zucker JD, Clement K, Henegar C. FunNet: an integrative tool for exploring transcriptional interactions. Bioinformatics. 2008 Nov 15;24(22):2636-8. Epub 2008 Sep 17. PubMed PMID: 18799481.

130. Capel F, Viguerie N, Vega N, Dejean S, Arner P, Klimcakova E, Martinez JA, Saris WH, Holst C, Taylor M, Oppert JM, Sørensen TI, Clément K, Vidal H, Langin D. Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women. J Clin Endocrinol Metab. 2008 Nov;93(11):4315-22. Epub 2008 Sep 9. PubMed PMID: 18782868.

131. Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. J Clin Endocrinol Metab. 2008 Dec;93(12):4955-62. Epub 2008 Sep 2. PubMed PMID: 18765507; PubMed Central PMCID: PMC2729235.

132. Silaghi A, Piercecchi-Marti MD, Grino M, Leonetti G, Alessi MC, Clement K, Dadoun F, Dutour A. Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy. Obesity (Silver Spring). 2008 Nov;16(11):2424-30. Epub 2008 Aug 14. PubMed PMID: 18719675.

133. Larrouy D, Barbe P, Valle C, Déjean S, Pelloux V, Thalamas C, Bastard JP, Le Bouil A, Diquet B, Clément K, Langin D, Viguerie N. Gene expression profiling of human skeletal muscle in response to stabilized weight loss. Am J Clin Nutr. 2008 Jul;88(1):125-32. PubMed PMID: 18614732.

134. Spielmann N, Mutch DM, Rousseau F, Tores F, Hager J, Bertrais S, Basdevant A, Tounian P, Dubern B, Galan P, Clément K. Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations. Clin Genet. 2008 Aug;74(2):155-63. Epub 2008 Jun 28. PubMed PMID: 18565099.

135. Oort PJ, Knotts TA, Grino M, Naour N, Bastard JP, Clément K, Ninkina N, Buchman VL, Permana PA, Luo X, Pan G, Dunn TN, Adams SH. Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity. J Nutr. 2008 May;138(5):841-8. PubMed PMID: 18424589.

136. Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008 Jan 21;9(1):R14. PubMed PMID: 18208606; PubMed Central PMCID: PMC2395253.

137. Dolley G, Bertrais S, Frochot V, Bebel JF, Guerre-Millo M, Tores F, Rousseau F, Hager J, Basdevant A, Hercberg S, Galan P, Oppert JM, Lacorte JM, Clément K. Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study. Int J Obes (Lond). 2008 Apr;32(4):669-75. Epub 2007 Dec 11. PubMed PMID: 18071343.

138. Guettier JM, Park JY, Cochran EK, Poitou C, Basdevant A, Meier M, Clément K, Magré J, Gorden P. Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation. Clin Endocrinol (Oxf). 2008 Apr;68(4):547-54. Epub 2007 Dec 10. PubMed PMID: 18076675; PubMed Central PMCID: PMC2578870.

139. Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr Res. 2008 Feb;63(2):211-6. PubMed PMID: 18091355.

2009

140. Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A, Aissat A, Guerre-Millo M, Clément K. Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab. 2009 Nov;94(11):4619-23. Epub 2009 Oct 16. PubMed PMID: 19837929.

141. Keophiphath M, Priem F, Jacquemond-Collet I, Clément K, Lacasa D. 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J Nutr. 2009 Nov;139(11):2055-60. Epub 2009 Sep 16. PubMed PMID: 19759245.

142. Lloret Linares C, Declèves X, Oppert JM, Basdevant A, Clement K, Bardin C, Scherrmann JM, Lepine JP, Bergmann JF, Mouly S. Pharmacology of morphine in obese patients: clinical implications. Clin Pharmacokinet. 2009;48(10):635-51. doi: 10.2165/11317150-000000000-00000. Review. PubMed PMID: 19743886.

143. Hartemann-Heurtier A, Halbron M, Golmard JL, Jacqueminet S, Bastard JP, Rouault C, Ayed A, Pieroni L, Clément K, Grimaldi A. Effects of bed-time insulin versus pioglitazone on abdominal fat accumulation, inflammation and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes Res Clin Pract. 2009 Oct;86(1):37-43. Epub 2009 Aug 15. PubMed PMID: 19683825.

144. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug;15(8):940-5. Epub 2009 Jul 26. PubMed PMID: 19633655; PubMed Central PMCID: PMC2736875.

145. Rome S, Meugnier E, Lecomte V, Berbe V, Besson J, Cerutti C, Pesenti S, Granjon A, Disse E, Clement K, Lefai E, Laville M, Vidal H. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2). Diabetologia. 2009 Sep;52(9):1899-912. Epub 2009 Jul 10. PubMed PMID: 19590847.

146. Tordjman J, Poitou C, Hugol D, Bouillot JL, Basdevant A, Bedossa P, Guerre-Millo M, Clement K. Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status. J Hepatol. 2009 Aug;51(2):354-62. Epub 2009 Apr 24. PubMed PMID: 19464069.

147. Clément K, Vignes S. [Inflammation, adipokines and obesity]. Rev Med Interne. 2009 Sep;30(9):824-32. Epub 2009 Apr 25. Review. French. PubMed PMID: 19394723.

148. Clément K, Basdevant A, Dutour A. Weight of pericardial fat on coronaropathy. Arterioscler Thromb Vasc Biol. 2009 May;29(5):615-6. PubMed PMID: 19369652.

149. Naour N, Fellahi S, Renucci JF, Poitou C, Rouault C, Basdevant A, Dutour A, Alessi MC, Bastard JP, Clément K, Guerre-Millo M. Potential contribution of adipose tissue to elevated serum cystatin C in human obesity. Obesity (Silver Spring). 2009 Dec;17(12):2121-6. Epub 2009 Apr 9. PubMed PMID: 19360013.

150. Mutch DM, Rouault C, Keophiphath M, Lacasa D, Clément K. Using gene expression to predict the secretome of differentiating human preadipocytes. Int J Obes (Lond). 2009 Mar;33(3):354-63. Epub 2009 Feb 17. PubMed PMID: 19223850.

151. Poitou C, Divoux A, Faty A, Tordjman J, Hugol D, Aissat A, Keophiphath M, Henegar C, Commans S, Clément K. Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux. J Clin Endocrinol Metab. 2009 May;94(5):1810-7. Epub 2009 Feb 17. PubMed PMID: 19223523.

152. Clément K, Le Stunff C, Meirhaeghe A, Dechartres A, Ferrieres J, Basdevant A, Boitard C, Amouyel P, Bougnères P. In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes. Mol Genet Metab. 2009 Mar;96(3):129-32. Epub 2008 Dec 18. PubMed PMID: 19097921.

153. Mutch DM, Tordjman J, Pelloux V, Hanczar B, Henegar C, Poitou C, Veyrie N, Zucker JD, Clément K. Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles. Am J Clin Nutr. 2009 Jan;89(1):51-7. Epub 2008 Dec 3. PubMed PMID: 19056587.

154. Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P. Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity. Diabetes. 2009 Jan;58(1):125-33. Epub 2008 Oct 24. PubMed PMID: 18952835; PubMed Central PMCID: PMC2606860.

155. Keophiphath M, Achard V, Henegar C, Rouault C, Clément K, Lacasa D. Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes. Mol Endocrinol. 2009 Jan;23(1):11-24. Epub 2008 Oct 22. PubMed PMID: 18945811.

156. Mallat Z, Simon T, Benessiano J, Clément K, Taleb S, Wareham NJ, Luben R, Khaw KT, Tedgui A, Boekholdt SM. Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women. J Clin Endocrinol Metab. 2009 Jan;94(1):255-60. Epub 2008 Oct 14. PubMed PMID: 18854400.

157. Mutch DM, Fuhrmann JC, Rein D, Wiemer JC, Bouillot JL, Poitou C, Clément K. Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. PLoS One. 2009 Nov 19;4(11):e7905. PubMed PMID: 19936240; PubMed Central PMCID: PMC2775672.

2010

158. Capuron L, Poitou C, Machaux-Tholliez D, Frochot V, Bouillot JL, Basdevant A, Layé S, Clément K. Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med. 2010 Oct 20:1-12. [Epub ahead of print] PubMed PMID: 20961476.

159. Prifti E, Zucker JD, Clément K, Henegar C. Interactional and functional centrality in transcriptional co-expression networks. Bioinformatics. 2010 Dec 15;26(24):3083-9. Epub 2010 Oct 19. PubMed PMID: 20959383.

160. Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, Mariat D, Corthier G, Doré J, Henegar C, Rizkalla S, Clément K. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 2010 Dec;59(12):3049-57. Epub 2010 Sep 28. PubMed PMID: 20876719; PubMed Central PMCID: PMC2992765.

161. Márquez-Quiñones A, Mutch DM, Debard C, Wang P, Combes M, Roussel B, Holst C, Martinez JA, Handjieva-Darlenska T, Kalouskova P, Jebb S, Babalis D, Pfeiffer AF, Larsen TM, Astrup A, Saris WH, Mariman E, Clément K, Vidal H, Langin D, Viguerie N; on behalf of the DiOGenes Project. Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake. Am J Clin Nutr. 2010 Aug 25. [Epub ahead of print] PubMed PMID: 20739421.

162. Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, Basdevant A, Guerre-Millo M, Poitou C, Zucker JD, Bedossa P, Clément K. Fibrosis in human adipose tissue: composition, distribution and link with lipid metabolism and fat mass loss. Diabetes. 2010 Nov;59(11):2817-25. Epub 2010 Aug 16. PubMed PMID: 20713683.

163. Roubert P, Dubern B, Plas P, Lubrano-Berthelier C, Alihi R, Auger F, Deoliveira DB, Dong JZ, Basdevant A, Thurieau C, Clemént K. Novel pharmacological MC4R agonists can efficiently activate mutated-MC4R from obese patients with impaired endogenous agonist response. J Endocrinol. 2010 Aug 9. [Epub ahead of print] PubMed PMID: 20696697.

164. Barr J, Vázquez-Chantada M, Alonso C, Pérez-Cormenzana M, Mayo R, Galán A, Caballería J, Martín-Duce A, Tran A, Wagner C, Luka Z, Lu SC, Castro A, Le Marchand-Brustel Y, Martínez-Chantar ML, Veyrie N, Clément K, Tordjman J, Gual P, Mato JM. Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J Proteome Res. 2010 Sep 3;9(9):4501-12. PubMed PMID: 20684516; PubMed Central PMCID: PMC2933275.

165. Tam CS, Viardot A, Clément K, Tordjman J, Tonks K, Greenfield JR, Campbell LV, Samocha-Bonet D, Heilbronn LK. Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes. 2010 Sep;59(9):2164-70. Epub 2010 Jun 14. PubMed PMID: 20547978.

166. Sun L, Yu Z, Ye X, Zou S, Li H, Yu D, Wu H, Chen Y, Dore J, Clément K, Hu FB, Lin X. A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes Care. 2010 Sep;33(9):1925-32. Epub 2010 Jun 8. PubMed PMID: 20530747; PubMed Central PMCID: PMC2928335.

167. Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C. Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors. Diabetes. 2010 Oct;59(10):2513-21. Epub 2010 Jun 8. PubMed PMID: 20530742.

168. Meas T, Carreira E, Wang Y, Rauh M, Poitou C, Clément K, Dötsch J, Lévy-Marchal C. 11beta-hydroxysteroid dehydrogenase type 1 of the subcutaneous adipose tissue is dysregulated but not associated with metabolic disorders in adults born small for gestational age. J Clin Endocrinol Metab. 2010 Aug;95(8):3949-54. Epub 2010 Jun 2. PubMed PMID: 20519348.

169. Lafarge JC, Naour N, Clément K, Guerre-Millo M. Cathepsins and cystatin C in atherosclerosis and obesity. Biochimie. 2010 Apr 24. [Epub ahead of print] PubMed PMID: 20417681.

170. Lloret Linares C, Hajj A, Poitou C, Simoneau G, Clement K, Laplanche JL, Lépine JP, Bergmann JF, Mouly S, Peoc'h K. Pilot Study Examining the Frequency of Several Gene Polymorphisms Involved in Morphine Pharmacodynamics and Pharmacokinetics in a Morbidly Obese Population. Obes Surg. 2010 Apr 22. [Epub ahead of print] PubMed PMID: 20411349.

171. Dahlman I, Mejhert N, Linder K, Agustsson T, Mutch DM, Kulyte A, Isaksson B, Permert J, Petrovic N, Nedergaard J, Sjölin E, Brodin D, Clement K, Dahlman-Wright K, Rydén M, Arner P. Adipose tissue pathways involved in weight loss of cancer cachexia. Br J Cancer. 2010 May 11;102(10):1541-8. Epub 2010 Apr 20. PubMed PMID: 20407445; PubMed Central PMCID: PMC2869165.

172. Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, Tordjman J, Eckel J, Clément K. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab. 2010 Jun;95(6):2892-6. Epub 2010 Apr 7. PubMed PMID: 20375212.

173. Naour N, Rouault C, Fellahi S, Lavoie ME, Poitou C, Keophiphath M, Eberlé D, Shoelson S, Rizkalla S, Bastard JP, Rabasa-Lhoret R, Clément K, Guerre-Millo M. Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. J Clin Endocrinol Metab. 2010 Apr;95(4):1861-8. Epub 2010 Feb 17. PubMed PMID: 20164293.

174. Tounian A, Aggoun Y, Lacorte JM, Dubern B, Clément K, Bonnet D, Tounian P. Influence of polymorphisms in candidate genes on early vascular alterations in obese children. Arch Cardiovasc Dis. 2010 Jan;103(1):10-8. Epub 2009 Nov 29. PubMed PMID: 20142115.

175. Dutour A, Achard V, Sell H, Naour N, Collart F, Gaborit B, Silaghi A, Eckel J, Alessi MC, Henegar C, Clément K. Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease. J Clin Endocrinol Metab. 2010 Feb;95(2):963-7. Epub 2009 Dec 11. PubMed PMID: 20008021.

176. Clement K, Gustafson N, Berbert A, Carroll H, Merris C, Olsen A, Clement M, Snell Q, Allen J, Roper RJ. PathGen: a transitive gene pathway generator. Bioinformatics. 2010 Feb 1;26(3):423-5. Epub 2009 Dec 4. PubMed PMID: 19965882.

177. Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D. CCL5 promotes macrophage recruitment and survival in human adipose tissue. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):39-45. Epub 2009 Nov 5. PubMed PMID: 19893003.

178. Tam CS, Clément K, Baur LA, Tordjman J. Obesity and low-grade inflammation: a paediatric perspective. Obes Rev. 2010 Feb;11(2):118-26. Epub 2009 Oct 21. Review. PubMed PMID: 19845868.

2011

179. Aron-Wisnewsky J, Julia Z, Poitou C, Bouillot JL, Basdevant A, Chapman MJ, Clement K, Guerin M. Effect of Bariatric Surgery-Induced Weight Loss on SR-BI, ABCG1-, and ABCA1-Mediated Cellular Cholesterol Efflux in Obese Women. J Clin Endocrinol Metab. 2011 Feb 2. [Epub ahead of print] PubMed PMID: 21289254.

180. Zimmermann E, Anty R, Tordjman J, Verrijken A, Gual P, Tran A, Iannelli A, Gugenheim J, Bedossa P, Francque S, Marchand-Brustel YL, Clement K, Van Gaal L, Sørensen TI, Jess T. C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients. J Hepatol. 2011 Jan 13. [Epub ahead of print] PubMed PMID: 21238518.

181. Kim MJ, Marchand P, Henegar C, Antignac JP, Alili R, Poitou C, Bouillot JL, Basdevant A, Le Bizec B, Barouki R, Clément K. Fate and Complex Pathogenic Effects of Dioxins and Polychlorinated Biphenyls in Obese Subjects before and after Drastic Weight Loss. Environ Health Perspect. 2011 Mar;119(3):377-83. Epub 2010 Dec 3. PubMed PMID: 21156398.

182. Mencarelli M, Dubern B, Alili R, Maestrini S, Benajiba L, Tagliaferri M, Galan P, Rinaldi M, Simon C, Tounian P, Hercberg S, Liuzzi A, Di Blasio AM, Clement K. Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity. Hum Mol Genet. 2011 Jan 15;20(2):392-9. Epub 2010 Nov 3. PubMed PMID: 21047972.

183. Stenson BM, Rydén M, Venteclef N, Dahlman I, Pettersson AM, Mairal A, Aström G, Blomqvist L, Wang V, Jocken JW, Clément K, Langin D, Arner P, Laurencikiene J.Liver X receptor (LXR) regulates human adipocyte lipolysis. J Biol Chem. 2011 Jan 7;286(1):370-9. Epub 2010 Oct 28. PubMed PMID: 21030586; PubMed Central PMCID: PMC3012995.

184. Richette P, Poitou C, Garnero P, Vicaut E, Bouillot JL, Lacorte JM, Basdevant A, Clément K, Bardin T, Chevalier X. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis. 2011 Jan;70(1):139-44. Epub 2010 Oct 26. PubMed PMID: 20980288.

185. Divoux A, Clément K. Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue. Obes Rev. 2011 May;12(5):e494-503. doi: 10.1111/j.1467-789X.2010.00811.x. Epub 2011 Mar 2. Review. PubMed PMID: 21366833.

186. Cancello R, Rouault C, Guilhem G, Bedel JF, Poitou C, Di Blasio AM, Basdevant A, Tordjman J, Clément K. Urokinase plasminogen activator receptor in adipose tissue macrophages of morbidly obese subjects. Obes Facts. 2011;4(1):17-25. Epub 2011 Feb 16. PubMed PMID: 21372607.

187. Jiao H, Arner P, Dickson SL, Vidal H, Mejhert N, Henegar C, Taube M, Hansson C, Hinney A, Galan P, Simon C, Silveira A, Benrick A, Jansson JO, Bouloumié A, Langin D, Laville M, Debard C, Axelsson T, Rydén M, Kere J, Dahlman-Wright K, Hamsten A, Clement K, Dahlman I. Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity. J Clin Endocrinol Metab. 2011 Jun;96(6):E962-6. Epub 2011 Mar 23. PubMed PMID: 21430024.

188. Hooton H, Dubern B, Henegar C, Paternoster L, Nohr EA, Alili R, Rousseau F, Pelloux V, Galan P, Hercberg S, Arner P, Sørensen TI, Clément K. Association between CST3 rs2424577 polymorphism and corpulence related phenotypes during lifetime in populations of European ancestry. Obes Facts. 2011;4(2):131-44. Epub 2011 Apr 15. PubMed PMID: 21577020.

189. Tam CS, Heilbronn LK, Henegar C, Wong M, Cowell CT, Cowley MJ, Kaplan W, Clément K, Baur LA. An early inflammatory gene profile in visceral adipose tissue in children. Int J Pediatr Obes. 2011 Jun;6(2-2):e360-3. Epub 2011 May 24. PubMed PMID: 21609243.

190. Dalmas E, Clément K, Guerre-Millo M. Defining macrophage phenotype and function in adipose tissue. Trends Immunol. 2011 Jul;32(7):307-14. Epub 2011 May 26. Review. PubMed PMID: 21616718.

191. Goossens GH, Bizzarri A, Venteclef N, Essers Y, Cleutjens JP, Konings E, Jocken JW, Cajlakovic M, Ribitsch V, Clément K, Blaak EE. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation. 2011 Jul 5;124(1):67-76. Epub 2011 Jun 13. PubMed PMID: 21670228.

192. Liao X, Sharma N, Kapadia F, Zhou G, Lu Y, Hong H, Paruchuri K, Mahabeleshwar GH, Dalmas E, Venteclef N, Flask CA, Kim J, Doreian BW, Lu KQ, Kaestner KH, Hamik A, Clément K, Jain MK. Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest. 2011 Jul 1;121(7):2736-49. doi: 10.1172/JCI45444. Epub 2011 Jun 13. PubMed PMID: 21670502.

193. Dalmas E, Rouault C, Abdennour M, Rovere C, Rizkalla S, Bar-Hen A, Nahon JL, Bouillot JL, Guerre-Millo M, Clément K, Poitou C. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction. Am J Clin Nutr. 2011 Aug;94(2):450-8. Epub 2011 Jun 15. PubMed PMID: 21677057.

194. Aron-Wisnewsky J, Minville C, Tordjman J, Lévy P, Bouillot JL, Basdevant A, Bedossa P, Clément K, Pépin JL. Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese. J Hepatol. 2011 May 19. [Epub ahead of print] PubMed PMID: 21703181.

195. Jiao H, Arner P, Hoffstedt J, Brodin D, Dubern B, Czernichow S, van't Hooft F, Axelsson T, Pedersen O, Hansen T, Sørensen TI, Hebebrand J, Kere J, Dahlman-Wright K, Hamsten A, Clement K, Dahlman I. Genome wide association study identifies KCNMA1 contributing to human obesity. BMC Med Genomics. 2011 Jun 28;4:51. PubMed PMID: 21708048; PubMed Central PMCID: PMC3148553.

196. Gaborit B, Kober F, Jacquier A, Moro PJ, Cuisset T, Boullu S, Dadoun F, Alessi MC, Morange P, Clément K, Bernard M, Dutour A. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat. Int J Obes (Lond). 2011 Jul 5. doi: 10.1038/ijo.2011.117. [Epub ahead of print] PubMed PMID: 21730964.

197. Heude B, Pelloux V, Forhan A, Bedel JF, Lacorte JM, Clément K, Charles MA; the EDEN Mother-Child Cohort Study Group. Association of the Pro12Ala and C1431T Variants of PPAR{gamma} and Their Haplotypes with Susceptibility to Gestational Diabetes. J Clin Endocrinol Metab. 2011 Jul 27. [Epub ahead of print] PubMed PMID: 21795447.

198. Poitou C, Dalmas E, Renovato M, Benhamo V, Hajduch F, Abdennour M, Kahn JF, Veyrie N, Rizkalla S, Fridman WH, Sautès-Fridman C, Clément K, Cremer I. CD14dimCD16+ and CD14+CD16+ Monocytes in Obesity and During Weight Loss: Relationships With Fat Mass and Subclinical Atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2322-30. Epub 2011 Jul 28. PubMed PMID: 21799175.

199. Ait-Omar A, Monteiro-Sepulveda M, Poitou C, Le Gall M, Cotillard A, Gilet J, Garbin K, Houllier A, Château D, Lacombe A, Veyrie N, Hugol D, Tordjman J, Magnan C, Serradas P, Clément K, Leturque A, Brot-Laroche E. GLUT2 Accumulation in Enterocyte Apical and Intracellular Membranes: A Study in Morbidly Obese Human Subjects and ob/ob and High Fat-Fed Mice. Diabetes. 2011 Aug 18. [Epub ahead of print] PubMed PMID: 21852673.

200. Jess T, Zimmermann E, Anty R, Tordjman J, Verrijken A, Gual P, Tran A, Iannelli A, Gugenheim J, Bedosa P, Francque S, Le Marchand-Brustel Y, Clement K, Van Gaal L, Sørensen TI. Authors' reply: C-reactive protein levels in non-alcoholic fatty liver disease. J Hepatol. 2011 Aug 31. [Epub ahead of print] PubMed PMID: 21888879.

201. Dalmas E, Tordjman J, Guerre-Millo M, Clément K. Adipose tissue, a new playground for immune cells. Med Sci (Paris). 2011 Nov;27(11):993-9. Epub 2011 Nov 30. French. PubMed PMID: 22130027.

202. Mutch DM, Pers TH, Temanni MR, Pelloux V, Marquez-Quiñones A, Holst C, Martinez JA, Babalis D, van Baak MA, Handjieva-Darlenska T, Walker CG, Astrup A, Saris WH, Langin D, Viguerie N, Zucker JD, Clément K; on behalf of the DiOGenes Project. A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. Am J Clin Nutr. 2011 Dec;94(6):1399-1409. Epub 2011 Oct 26. PubMed PMID: 22030226.

203. Gaborit B, Kober F, Jacquier A, Moro PJ, Flavian A, Quilici J, Cuisset T, Simeoni U, Cozzone P, Alessi MC, Clément K, Bernard M, Dutour A. Epicardial Fat Volume Is Associated With Coronary Microvascular Response in Healthy Subjects: A Pilot Study. Obesity (Silver Spring). 2011 Oct 6. doi: 10.1038/oby.2011.283. [Epub ahead of print] PubMed PMID: 21979392.

204. Clément K. Bariatric surgery, adipose tissue and gut microbiota. Int J Obes (Lond). 2011 Sep;35 Suppl 3:S7-15. doi: 10.1038/ijo.2011.141. PubMed PMID: 21912389.

205. Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, Esposito K, Jönsson LS, Kolb H, Lansink M, Marcos A, Margioris A, Matusheski N, Nordmann H, O'Brien J, Pugliese G, Rizkalla S, Schalkwijk C, Tuomilehto J, Wärnberg J, Watzl B, Winklhofer-Roob BM. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011 Dec;106 Suppl 3:S5-S78. PubMed PMID: 22133051.

2012

206. Tordjman J, Divoux A, Prifti E, Poitou C, Pelloux V, Hugol D, Basdevant A, Bouillot JL, Chevallier JM, Bedossa P, Guerre-Millo M, Clement K. Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity. J Hepatol. 2012 Jan 12. [Epub ahead of print] PubMed PMID: 22245892.

207. Tam CS, Tordjman J, Divoux A, Baur LA, Clément K. Adipose Tissue Remodeling in Children: The Link between Collagen Deposition and Age-Related Adipocyte Growth. J Clin Endocrinol Metab. 2012 Jan 18. [Epub ahead of print] PubMed PMID: 22259057.

208. Kim MJ, Pelloux V, Guyot E, Tordjman J, Bui LC, Chevallier A, Forest C, Benelli C, Clément K, Barouki R. Inflammatory Pathway Genes belong to Major Targets of Persistent Organic Pollutants in Adipose Cells. Environ Health Perspect. 2012 Jan 19. [Epub ahead of print] PubMed PMID: 22262711.

209. Rizkalla SW, Prifti E, Cotillard A, Pelloux V, Rouault C, Allouche R, Laromiguière M, Kong L, Darakhshan F, Massiera F, Clement K. Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial. Am J Clin Nutr. 2012 Jan;95(1):49-63. Epub 2011 Dec 14. PubMed PMID: 22170375.

210.