J. Clin. Endocrinol. Metab. 2012 Sep;97(9):E1677-85
AIMS AND HYPOTHESIS: Mast cells are immune cells known for their role in several inflammatory and fibrotic diseases. Recent works ...
PLoS ONE 2012;7(7):e40394
BACKGROUND/AIMS: Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology--this protein enhances adi...
PLoS ONE 2012;7(6):e39930
BACKGROUND: Blockade of the renin-angiotensin system (RAS) reduces the incidence of type 2 diabetes mellitus. In rodents, it has b...
Obesity (Silver Spring) 2012 Jun;20(6):1200-5
Epicardial fat (EF) is an active ectopic fat depot, which has been associated with coronary atherosclerosis, and which could early influence endoth...
J. Hepatol. 2012 May;56(5):1152-8
BACKGROUND & AIMS: In addition to total body fat, the regional distribution and inflammatory status of enlarged adipose tissue are...
J. Clin. Endocrinol. Metab. 2012 Apr;97(4):1320-7
CONTEXT: Extracellular matrix (ECM) remodeling is essential for adipose tissue growth and expansion in high fat-fed mice, and ther...
J. Proteome Res. 2012 Apr;11(4):2521-32
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is...
Environ. Health Perspect. 2012 Apr;120(4):508-14
BACKGROUND: Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabol...
PLoS ONE 2012;7(3):e30325
BACKGROUND: Liver biopsy is considered as the gold standard for assessing non-alcoholic fatty liver disease (NAFLD) histologic les...
N. Engl. J. Med. 2012 Mar;366(11):1064-5
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Mol. Immunol. 2012 Mar;50(3):142-9
Recent studies in rodents indicate that the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammaso...
Am. J. Clin. Nutr. 2012 Jan;95(1):49-63
BACKGROUND: The most effective and safe dietary approach for weight loss and its impact on the metabolic functions and morphology ...
J. Hepatol. 2012 Jan;56(1):225-33
BACKGROUND & AIMS: Morbid obesity is frequently associated with low grade systemic inflammation, increased macrophage accumulation...
Lancet 1992 Aug;340(8817):444-8
Maturity-onset diabetes of the young (MODY), characterised by non-insulin-dependent diabetes mellitus (NIDDM) with an early age of onset, is a gene...