December 2022

February 2022

Microbiome and metabolome features of the cardiometabolic disease spectrum

By |2023-03-27T14:30:14+02:00February 17, 2022|

Nat Med. 2022 Feb;28(2):303-314. doi: 10.1038/s41591-022-01688-4
Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid conditions, or polypharmacy....

Adipose Tissue Fibrosis in Obesity: Etiology and Challenges

By |2023-03-27T14:21:58+02:00February 10, 2022|

Annu Rev Physiol. 2022 Feb 10;84:135-155. doi: 10.1146/annurev-physiol-060721-092930
Obesity is a chronic and progressive process affecting whole-body energy balance and is associated with comorbidity development...

January 2022

The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass

By |2023-03-27T14:30:41+02:00January 11, 2022|

Gut Microbes 14,1 (2022). doi: 10.1080/19490976.2022.2050635
Roux-en-Y gastric bypass (RYGB) is efficient at inducing drastic albeit variable weight loss and type-2 diabetes (T2D) improvements in patients with severe obesity and T2D...

March 2021

Intestinal alteration of α-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission

By |2023-03-27T14:29:40+02:00March 21, 2021|

Am J Physiol Endocrinol Metab 321, 3 (2021). doi: 10.1152/ajpendo.00071.2021
Carbohydrates and sweeteners are detected by the sweet taste receptor in enteroendocrine cells (EECs). This receptor is coupled to the gustducin G-protein, which α-subunit is encoded by GNAT3 gene...

January 2021

Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health-Pathophysiology and Therapeutic Strategies

By |2023-03-27T14:28:00+02:00January 21, 2021|

J. Gastroenterol. 160, 2 (2021). doi: 10.1053/j.gastro.2020.10.057
Changes in the intestinal microbiome have been associated with obesity and type 2 diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free mice...

November 2020

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

By |2020-11-18T17:32:43+01:00November 18, 2020|

Nat Commun 11, 5881 (2020).
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism...

Weight Loss After Sleeve Gastrectomy: Does Type 2 Diabetes Status Impact Weight and Body Composition Trajectories?

By |2020-11-18T15:49:37+01:00November 4, 2020|

Obes Surg. 2020 Nov 4. doi: 10.1007/s11695-020-05075-1.
Sleeve gastrectomy (SG), the most frequently performed bariatric procedure, induces marked weight-loss, but with high inter-individual variability...

Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy

By |2020-11-18T17:35:16+01:00November 3, 2020|

Diabetes. 2020 Nov 2:db200578. doi: 10.2337/db20-0578
Besides cytoplasmic lipase-dependent adipocyte fat mobilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes is unclear.

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials

By |2020-11-18T17:37:45+01:00November 2, 2020|

Lancet Diabetes Endocrinol. 2020 Oct 30:S2213-8587(20)30364-8.
The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused by biallelic variants in genes that affect the MC4R pathway...

October 2020

Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity

By |2020-11-18T15:45:50+01:00October 30, 2020|

Diabetologia. 2020 Oct 30. doi: 10.1007/s00125-020-05307-0.
Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice.

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

By |2020-11-18T16:22:35+01:00October 12, 2020|

PLoS Genet. 2020 Oct 12;16(10):e1008718. doi: 10.1371/journal.pgen.1008718. eCollection 2020 Oct
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown.

Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity

By |2020-11-18T15:38:07+01:00October 10, 2020|

Int J Obes. 2020 Oct 9. doi: 10.1038/s41366-020-00694-1.
Altered enteroendocrine cell (EEC) function in obesity and type 2 diabetes is not fully understood. Understanding the transcriptional program that controls EEC differentiation is important because some EEC types harbor significant therapeutic potential for type 2 diabetes.

September 2020

Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance

By |2020-11-18T15:52:35+01:00September 30, 2020|

Diabetes. 2020 Sep 29:db200647. doi: 10.2337/db20-0647.
Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes.

COVID-19 and its severity in bariatric surgery operated patients

By |2020-11-18T16:46:50+01:00September 3, 2020|

Obesity (Silver Spring). 2020 Sep 1. doi: 10.1002/oby.23026.
Obesity is a major risk factor of severe forms of COVID‐19 but little is known about the post bariatric surgery (BS) setting...

August 2020

Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain

By |2020-11-18T17:06:24+01:00August 30, 2020|

Gastroenterology. 2020 Aug 26:S0016-5085(20)35111-8. doi: 10.1053/j.gastro.2020.08.041.
We evaluated the efficacy and safety of diet-modulated autologous fecal microbiota transplantation (aFMT) for treatment of weight regain after the weight-loss phase....

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

By |2020-11-18T17:39:16+01:00August 3, 2020|

EBioMedicine. 2020 Aug;58:102895. doi: 10.1016/j.ebiom.2020.102895.
Bariatric surgery is an effective treatment for type 2 diabetes. Early post-surgical enhancement of insulin secretion is key for diabetes remission...

June 2020

Revealing links between gut microbiome and its fungal community in Type 2 Diabetes Mellitus among Emirati subjects: A pilot study

By |2020-11-18T17:40:06+01:00June 17, 2020|

Sci Rep. 2020 Jun 15;10(1):9624. doi: 10.1038/s41598-020-66598-2.
Type 2 diabetes mellitus (T2DM) drastically affects the population of Middle East countries with an ever-increasing number of overweight and obese individuals. The precise links between T2DM and gut microbiome composition remain elusive in these populations...

What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice: Summary from a Pennington Scientific Symposium

By |2020-11-18T17:00:14+01:00June 11, 2020|

Obesity (Silver Spring). 2020 Aug;28(8):1386-1396. doi: 10.1002/oby.22806. Epub 2020 Jun 10.
This review details the proceedings of a Pennington Biomedical scientific symposium titled, “What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice"...

COVID-19: A Lever for the Recognition of Obesity as a Disease? The French Experience

By |2020-11-18T16:50:30+01:00June 5, 2020|

Obesity (Silver Spring). 2020 Sep;28(9):1584-1585. doi: 10.1002/oby.22924.
Despite repeated efforts by the international scientific community, academic societies, and the combined actions of patient associations, public authorities have difficulties in admitting that obesity is not just a risk factor but a disease...

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