Nutriomics | Nutrition and Obesities: Systemic Approaches

TOPIC 1

Progression of obesity and related complications: role of gut microbiota?

TOPIC 2

Intestine as a key player in metabolic disorders

TOPIC 3

Adipose tissue Remodeling

TOPIC 4

Systems’ biology and data integration (transversal WP)

TOPIC 5

Translating our fundamental research for the benefit of patients.

Define gut microbiota signature in CMD and evaluate the impact of environment (diet and drugs)
Demonstrate causality of CMD microbial signature in the development of CMD or its resolution:
- in human interventions: Metacardis follow-up (development), diet or bariatric surgery (reversal)
- in mice: gut microbiota transfer experiments (induce CMD or its reversal)

The intestine is a target for changes in external (food, microbiota) and internal (immune system) environment. Gut adaptation has in turn consequences on gut immunity, epithelial cells homeostasis and key organs for energy balance.

Understand WAT fibrosis : role of progenitors:
Characterize WAT senescence :
- Evaluate inappropriate turnover of subcellular components (Lysosomal degradation)
- Examine PG as gut-derived signaling modulators in AT remodeling

We will develop innovative tools for data analysis, physiological status prediction, and visualisation in metabolic diseases. Convergence of techniques include statistical inferences, machine learning, and mechanistic approach using dynamical systems. This WP is strongly integrated with the other WPs which produce large-scale data.

Two main axes

Develop innovative diagnosis and predictive factors/tools:
Develop novel approaches for therapy with personalized medicine

Latest Publications

Long-term Relapse of Type 2 Diabetes After Roux-en-Y Gastric Bypass: Prediction and Clinical Relevance

August 18, 2018|Comments Off on Long-term Relapse of Type 2 Diabetes After Roux-en-Y Gastric Bypass: Prediction and Clinical Relevance

Diabetes Care 2018 Aug;
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) induces type 2 diabetes remission (DR) in 60% of patients at 1 year, yet long-term rela...

Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes

July 18, 2018|Comments Off on Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes

J. Pathol. 2018 Jul;
Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammatio...

Gut microbiota and obesity: Concepts relevant to clinical care

March 8, 2018|Comments Off on Gut microbiota and obesity: Concepts relevant to clinical care

Eur. J. Intern. Med. 2018 Feb;48:18-24
The composition and function of gut microbiota play a role in obesity and metabolic disease, yet the mechanisms have not been fully described. As n...

The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass

July 22, 2017|Comments Off on The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass

Diabetologia 2017 Jul;
AIMS/HYPOTHESIS: Not all people with type 2 diabetes who undergo bariatric surgery achieve diabetes remission. Thus it is critical...

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

June 8, 2017|Comments Off on Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

Sci Rep 2017 Jun;7(1):3000
Adipose tissue contains a variety of immune cells, which vary in abundance and phenotype with obesity. The contribution of immune cell-derived fact...

The FAT Score, a Fibrosis Score of Adipose Tissue: Predicting Weight-Loss Outcome After Gastric Bypass

April 18, 2017|Comments Off on The FAT Score, a Fibrosis Score of Adipose Tissue: Predicting Weight-Loss Outcome After Gastric Bypass

J. Clin. Endocrinol. Metab. 2017 Jul;102(7):2443-2453
Context: Bariatric surgery (BS) induces major and sustainable weight loss in many patients. Factors predicting poor weight-loss re...

Prospective assessment and histological analysis of adherent perinephric fat in partial nephrectomies

March 25, 2017|Comments Off on Prospective assessment and histological analysis of adherent perinephric fat in partial nephrectomies

Urol. Oncol. 2017 Feb;35(2):39.e9-39.e17
OBJECTIVES: The complexity of partial nephrectomy (PN) is partly anticipated by morphometric tumor-based scores that do not consid...

Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis

March 16, 2017|Comments Off on Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis

Ann. Rheum. Dis. 2017 Jun;76(6):1142-1148
OBJECTIVES: Compared with subcutaneous adipose tissue (SCAT), infrapatellar fat pad (IFP), the main knee intra-articular adipose t...