Nutriomics | Nutrition and Obesities: Systemic Approaches

TOPIC 1

Progression of obesity and related complications: role of gut microbiota?

TOPIC 2

Intestine as a key player in metabolic disorders

TOPIC 3

Adipose tissue Remodeling

TOPIC 4

Systems’ biology and data integration (transversal WP)

TOPIC 5

Translating our fundamental research for the benefit of patients.

Define gut microbiota signature in CMD and evaluate the impact of environment (diet and drugs)
Demonstrate causality of CMD microbial signature in the development of CMD or its resolution:
- in human interventions: Metacardis follow-up (development), diet or bariatric surgery (reversal)
- in mice: gut microbiota transfer experiments (induce CMD or its reversal)

The intestine is a target for changes in external (food, microbiota) and internal (immune system) environment. Gut adaptation has in turn consequences on gut immunity, epithelial cells homeostasis and key organs for energy balance.

Understand WAT fibrosis : role of progenitors:
Characterize WAT senescence :
- Evaluate inappropriate turnover of subcellular components (Lysosomal degradation)
- Examine PG as gut-derived signaling modulators in AT remodeling

We will develop innovative tools for data analysis, physiological status prediction, and visualisation in metabolic diseases. Convergence of techniques include statistical inferences, machine learning, and mechanistic approach using dynamical systems. This WP is strongly integrated with the other WPs which produce large-scale data.

Two main axes

Develop innovative diagnosis and predictive factors/tools:
Develop novel approaches for therapy with personalized medicine

Latest Publications

Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years

May 14, 2019|Comments Off on Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years

Pediatr Obes 2019 05;14(5):e12496
BACKGROUND: Many genetic polymorphisms identified by genome-wide association studies for adult body mass index (BMI) have been sug...

Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?

April 25, 2019|Comments Off on Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?

Semin Immunopathol 2019 Apr;
Obesity is a chronic low-grade inflammatory disease (both at the systemic and adipose tissue level) that continues to rise worldwide. It is associa...

Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity

April 11, 2019|Comments Off on Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity

FASEB J. 2019 Apr;33(4):4741-4754
Lipidomic techniques can improve our understanding of complex lipid interactions that regulate metabolic diseases. Here, a serum phospholipidomics ...

Synergistic convergence of microbiota-specific systemic IgG and secretory IgA

April 1, 2019|Comments Off on Synergistic convergence of microbiota-specific systemic IgG and secretory IgA

J. Allergy Clin. Immunol. 2019 Apr;143(4):1575-1585.e4
BACKGROUND: Commensals induce local IgA responses essential to the induction of tolerance to gut microbiota, but it remains unclea...

Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials

March 30, 2019|Comments Off on Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials

BMJ Open 2019 Mar;9(3):e017995
OBJECTIVE: To systematically review the effect of oral intake of bacterial probiotics on 15 variables related to obesity, diabetes...

Prediction of Long-Term Diabetes Remission After RYGB, Sleeve Gastrectomy, and Adjustable Gastric Banding Using DiaRem and Advanced-DiaRem Scores

March 29, 2019|Comments Off on Prediction of Long-Term Diabetes Remission After RYGB, Sleeve Gastrectomy, and Adjustable Gastric Banding Using DiaRem and Advanced-DiaRem Scores

Obes Surg 2019 Mar;29(3):796-804
PURPOSE: DiaRem is a clinical scoring system designed to predict diabetes remission (DR) 1-year post-Roux-en-Y gastric bypass (RYG...

A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity

February 5, 2019|Comments Off on A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity

Front Physiol 2018;9:1958
The mechanisms responsible for calorie restriction (CR)-induced improvement in insulin sensitivity (IS) have not been fully elucidated. Greater in...

Comparative Evaluation of Microbiota Engraftment Following Fecal Microbiota Transfer in Mice Models: Age, Kinetic and Microbial Status Matter

January 14, 2019|Comments Off on Comparative Evaluation of Microbiota Engraftment Following Fecal Microbiota Transfer in Mice Models: Age, Kinetic and Microbial Status Matter

Front Microbiol 2018;9:3289
The intestinal microbiota and its functions are intricately interwoven with host physiology. Colonizing rodents with donor microbiota provides insi...