Aldosterone promotes cardiac endothelial cell proliferation in vivo
J Am Heart Assoc 2015 Jan;4(1):e001266
BACKGROUND: Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation thro...
January 2015
December 2014
Associations between genetic obesity susceptibility and early postnatal fat and lean mass: an individual participant meta-analysis
JAMA Pediatr 2014 Dec;168(12):1122-30
IMPORTANCE: Patterns of body size and body composition associated with genetic obesity susceptibility inform the mechanisms that i...
November 2014
Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation
Diabetes 2014 Dec;63(12):4032-44
Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic di...
October 2014
Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects
PLoS ONE 2014;9(10):e109434
BACKGROUND: Associations between dietary patterns, metabolic and inflammatory markers and gut microbiota are yet to be elucidated....
Medication cost is significantly reduced after Roux-en-Y gastric bypass in obese patients
Obes Surg 2014 Nov;24(11):1896-903
BACKGROUND: This study aims to determine the influence of Roux-en-Y gastric bypass (RYGB) on medication-related costs.
August 2014
Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulin resistance after gastric bypass
J. Clin. Endocrinol. Metab. 2014 Aug;99(8):E1466-70
CONTEXT: Adipocyte volume has been associated with insulin resistance and type 2 diabetes.OBJECTIVE: Our p...
July 2014
Cathepsin S inhibition lowers blood glucose levels in mice
Diabetologia 2014 Aug;57(8):1674-83
AIMS/HYPOTHESIS: Cathepsin S (CatS) belongs to a family of proteases that have been implicated in several disease processes. We pr...
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Nat Commun 2014 Jun;5:4309
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly associated with the metabolic syndrome, that can lead to pr...
June 2014
Association between melanocortin-4 receptor mutations and eating behaviors in obese patients: a case–control study
Int J Obes (Lond) 2014 Jun;38(6):883-5
Melanocortin-4 receptor (MC4R) gene mutations are involved in the leptin-melanocortin pathways that control food intake. The effect of these mutati...
May 2014
T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes
Diabetes 2014 Jun;63(6):1966-77
Proinflammatory cytokines are critically involved in the alteration of adipose tissue biology leading to deterioration of glucose homeostasis in ob...
Human adipocyte function is impacted by mechanical cues
J. Pathol. 2014 Jun;233(2):183-95
Fibrosis is a hallmark of human white adipose tissue (WAT) during obesity-induced chronic inflammation. The functional impact of increased intersti...
Association of adipose tissue and liver fibrosis with tissue stiffness in morbid obesity: links with diabetes and BMI loss after gastric bypass
J. Clin. Endocrinol. Metab. 2014 Mar;99(3):898-907
CONTEXT: Liver and white adipose tissue (WAT) develop inflammation and fibrosis.OBJECTIVE: The aim of the ...
Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma
Mol. Immunol. 2014 Jul;60(1):54-61
Polyreactive antibodies represent a significant fraction of immune repertoires and play an important role in the immune defense and immune homeosta...
March 2014
Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men
PLoS ONE 2014;9(3):e91375
MicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity. An important role of microRNA-1...
Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea
Chest 2014 Mar;145(3):525-533
BACKGROUND: Nocturnal hypoxia, the hallmark of OSA, is a potential contributing factor for nonalcoholic fatty liver disease (NAFLD...
January 2014
Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a three-dimensional setting: partial rescue by angiopoietin-1
Diabetes 2014 Feb;63(2):535-49
During obesity, chronic inflammation of human white adipose tissue (WAT) is associated with metabolic and vascular alterations. Endothelial cells f...
November 2013
Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach
Am. J. Clin. Nutr. 2013 Dec;98(6):1385-94
BACKGROUND: The ability to identify obese subjects who will lose weight in response to energy restriction is an important strategy...
October 2013
Intima-media thickness in severe obesity: links with BMI and metabolic status but not with systemic or adipose tissue inflammation
Diabetes Care 2013 Nov;36(11):3793-802
OBJECTIVE: Obesity is associated with cardiovascular risk and a low-grade inflammatory state in both blood and adipose tissue (AT)...
September 2013
Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity
Int J Obes (Lond) 2013 Sep;37(9):1198-203
CONTEXT: The care of patients with hypothalamic obesity is challenging.OBJECTIVE: To compare body composit...
August 2013
Richness of human gut microbiome correlates with metabolic markers
Nature 2013 Aug;500(7464):541-6
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population ...