Dietary intervention impact on gut microbial gene richness
Nature 2013 Aug;500(7464):585-8
Complex gene-environment interactions are considered important in the development of obesity. The composition of the gut microbiota can determine t...
August 2013
Noninvasive diagnosis of nonalcoholic steatohepatitis disease based on clinical decision support system
Stud Health Technol Inform 2013;192:1178
Non-alcoholic fatty liver disease (NAFLD) is a hepatic disease associated with metabolic syndrome. NAFLD covers a spectrum of liver disease from st...
July 2013
Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Diabetologia 2013 Aug;56(8):1792-801
AIMS/HYPOTHESIS: Alterations in white adipose tissue (WAT) function, including changes in protein (adipokine) secretion and extrac...
June 2013
Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes
Am. J. Clin. Nutr. 2013 Jul;98(1):16-24
BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for treating morbid obesity and result...
Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders
PLoS ONE 2013;8(6):e66788
OBJECTIVE: Evidence points to a founder of the multifunctional CCN family, NOV/CCN3, as a circulating molecule involved in cardiac...
April 2013
Therapeutic factor VIII does not trigger TLR1.2 and TLR2.6 signalling in vitro
Haemophilia 2013 May;19(3):399-402
The administration of therapeutic factor VIII (FVIII) to patients with haemophilia A induces the development of inhibitory anti-FVIII IgG in a subs...
March 2013
Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels
Arterioscler. Thromb. Vasc. Biol. 2013 Apr;33(4):822-8
OBJECTIVE: We investigated the impact of several genetic variants located in genes encoding for proteins involved in biogenesis, m...
February 2013
Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue
Endocrinology 2013 Mar;154(3):1069-79
The hypertrophied white adipose tissue (WAT) during human obesity produces inflammatory mediators, including cytokines (IL-6 and TNFα) and chemoki...
Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range
Atherosclerosis 2013 Mar;227(1):165-71
OBJECTIVES: To identify key determinants of plasma endogenous CETP activity and threshold value of plasma CETP activity associated...
January 2013
Neutral lipid storage disease with myopathy: a whole-body nuclear MRI and metabolic study
Mol. Genet. Metab. 2013 Feb;108(2):125-31
Neutral lipid storage disease with myopathy (NLSDM) is caused by a mutation in the gene encoding adipose triglyceride lipase (ATGL), and is charact...
Aldosterone-specific activation of cardiomyocyte mineralocorticoid receptor in vivo
Hypertension 2013 Feb;61(2):361-7
Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleteriou...
SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation
J. Clin. Invest. 2013 Jan;123(1):362-79
Low-grade chronic inflammation is a major characteristic of obesity and results from deregulated white adipose tissue function. Consequently, there...
December 2012
The dynamics of accumulation of PCBs in cultured adipocytes vary with the cell lipid content and the lipophilicity of the congener
Toxicol. Lett. 2013 Jan;216(1):40-6
Lipophilic pollutants such as polychlorinated biphenyls (PCBs) accumulate in high amounts in the adipose tissue. Recent epidemiological studies cor...
November 2012
Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
Mol. Endocrinol. 2012 Dec;26(12):1980-90
The liver plays a pivotal role in the physiological adaptation to fasting and a better understanding of the metabolic adaptive responses may give h...
Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery
PLoS ONE 2012;7(11):e48221
Bariatric surgery is the most effective long term weight-loss therapy for severe and morbidly obese patients. Melanocortin-4 Receptor (MC4R) mutati...
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
Hepatology 2012 Nov;56(5):1751-9
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and being overweight is a significant risk factor. The ai...
October 2012
Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content
J. Am. Coll. Cardiol. 2012 Oct;60(15):1381-9
OBJECTIVES: This study investigated the effect of bariatric surgery (BS)-induced weight loss on cardiac ectopic fat using 3T magne...
Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation
PLoS Genet. 2012 Sep;8(9):e1002959
Weight control diets favorably affect parameters of the metabolic syndrome and delay the onset of diabetic complications. The adaptations occurring...
September 2012
Elevated CETP activity improves plasma cholesterol efflux capacity from human macrophages in women
Arterioscler. Thromb. Vasc. Biol. 2012 Oct;32(10):2341-9
OBJECTIVE: We aim to identify the impact of endogenous cholesteryl ester transfer protein (CETP) activity on plasma capacity to me...
Relevance of increased serum cystatin C to vascular alterations in obese children
Pediatr Obes 2012 Oct;7(5):374-81
OBJECTIVE: Epidemiological studies report a positive relationship between serum cystatin C and cardiovascular outcomes in adults. ...