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18 11, 2020

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

By |2020-11-18T17:32:43+01:00November 18, 2020|

Nat Commun 11, 5881 (2020). https://doi.org/10.1038/s41467-020-19589-w
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism...

4 11, 2020

Weight Loss After Sleeve Gastrectomy: Does Type 2 Diabetes Status Impact Weight and Body Composition Trajectories?

By |2020-11-18T15:49:37+01:00November 4, 2020|

Obes Surg. 2020 Nov 4. doi: 10.1007/s11695-020-05075-1.
Sleeve gastrectomy (SG), the most frequently performed bariatric procedure, induces marked weight-loss, but with high inter-individual variability...

3 11, 2020

Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy

By |2020-11-18T17:35:16+01:00November 3, 2020|

Diabetes. 2020 Nov 2:db200578. doi: 10.2337/db20-0578
Besides cytoplasmic lipase-dependent adipocyte fat mobilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes is unclear.

2 11, 2020

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials

By |2020-11-18T17:37:45+01:00November 2, 2020|

Lancet Diabetes Endocrinol. 2020 Oct 30:S2213-8587(20)30364-8.
The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused by biallelic variants in genes that affect the MC4R pathway...

30 10, 2020

Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity

By |2020-11-18T15:45:50+01:00October 30, 2020|

Diabetologia. 2020 Oct 30. doi: 10.1007/s00125-020-05307-0.
Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice.

12 10, 2020

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

By |2020-11-18T16:22:35+01:00October 12, 2020|

PLoS Genet. 2020 Oct 12;16(10):e1008718. doi: 10.1371/journal.pgen.1008718. eCollection 2020 Oct
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown.

10 10, 2020

Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity

By |2020-11-18T15:38:07+01:00October 10, 2020|

Int J Obes. 2020 Oct 9. doi: 10.1038/s41366-020-00694-1.
Altered enteroendocrine cell (EEC) function in obesity and type 2 diabetes is not fully understood. Understanding the transcriptional program that controls EEC differentiation is important because some EEC types harbor significant therapeutic potential for type 2 diabetes.

30 09, 2020

Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance

By |2020-11-18T15:52:35+01:00September 30, 2020|

Diabetes. 2020 Sep 29:db200647. doi: 10.2337/db20-0647.
Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes.

3 09, 2020

COVID-19 and its severity in bariatric surgery operated patients

By |2020-11-18T16:46:50+01:00September 3, 2020|

Obesity (Silver Spring). 2020 Sep 1. doi: 10.1002/oby.23026.
Obesity is a major risk factor of severe forms of COVID‐19 but little is known about the post bariatric surgery (BS) setting...

30 08, 2020

Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain

By |2020-11-18T17:06:24+01:00August 30, 2020|

Gastroenterology. 2020 Aug 26:S0016-5085(20)35111-8. doi: 10.1053/j.gastro.2020.08.041.
We evaluated the efficacy and safety of diet-modulated autologous fecal microbiota transplantation (aFMT) for treatment of weight regain after the weight-loss phase....

3 08, 2020

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

By |2020-11-18T17:39:16+01:00August 3, 2020|

EBioMedicine. 2020 Aug;58:102895. doi: 10.1016/j.ebiom.2020.102895.
Bariatric surgery is an effective treatment for type 2 diabetes. Early post-surgical enhancement of insulin secretion is key for diabetes remission...

17 06, 2020

Revealing links between gut microbiome and its fungal community in Type 2 Diabetes Mellitus among Emirati subjects: A pilot study

By |2020-11-18T17:40:06+01:00June 17, 2020|

Sci Rep. 2020 Jun 15;10(1):9624. doi: 10.1038/s41598-020-66598-2.
Type 2 diabetes mellitus (T2DM) drastically affects the population of Middle East countries with an ever-increasing number of overweight and obese individuals. The precise links between T2DM and gut microbiome composition remain elusive in these populations...

11 06, 2020

What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice: Summary from a Pennington Scientific Symposium

By |2020-11-18T17:00:14+01:00June 11, 2020|

Obesity (Silver Spring). 2020 Aug;28(8):1386-1396. doi: 10.1002/oby.22806. Epub 2020 Jun 10.
This review details the proceedings of a Pennington Biomedical scientific symposium titled, “What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice"...

5 06, 2020

COVID-19: A Lever for the Recognition of Obesity as a Disease? The French Experience

By |2020-11-18T16:50:30+01:00June 5, 2020|

Obesity (Silver Spring). 2020 Sep;28(9):1584-1585. doi: 10.1002/oby.22924.
Despite repeated efforts by the international scientific community, academic societies, and the combined actions of patient associations, public authorities have difficulties in admitting that obesity is not just a risk factor but a disease...

21 05, 2020

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

By |2020-11-18T17:19:35+01:00May 21, 2020|

Nature. 2020 May;581(7808):310-315. doi: 10.1038/s41586-020-2269-x.
Microbiome community typing analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in loose stools in humans.

4 05, 2020

AhR activation defends gut barrier integrity against damage occurring in obesity

By |2020-11-18T16:33:39+01:00May 4, 2020|

Mol Metab. 2020 Sep;39:101007. doi: 10.1016/j.molmet.2020.101007. Epub 2020 Apr 28.
Obesity is characterized by systemic and low-grade tissue inflammation. In the intestine, alteration of the intestinal barrier and accumulation of inflammatory cells in the epithelium are important contributors of gut inflammation...

21 04, 2020

Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts

By |2020-11-18T16:00:53+01:00April 21, 2020|

PPAR Res. 2020 Apr 1;2020:9210748. doi: 10.1155/2020/9210748. eCollection 2020.
Trophoblasts, as the cells that make up the main part of the placenta, undergo cell differentiation processes such as invasion, migration, and fusion.

17 04, 2020

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort

By |2020-11-18T17:12:03+01:00April 17, 2020|

J Hepatol. 2020 Sep;73(3):505-515. doi: 10.1016/j.jhep.2020.04.003.
Genetic factors associated with non-alcoholic fatty liver disease (NAFLD) remain incompletely understood. To date, most genome-wide association studies...

11 03, 2020

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

By |2020-11-18T17:28:20+01:00March 11, 2020|

Nat Rev Gastroenterol Hepatol. 2020 May;17(5):279-297. doi: 10.1038/s41575-020-0269-9.
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease (NAFLD).

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