Authors: Maud Alligier, Romain Barrès, Ellen E. Blaak, Yves Boirie, Jildau Bouwman, Paul Brunault, Kristina Campbell, Karine Clément, I. Sadaf Farooqi, Nathalie J. Farpour-Lambert, Gema Frühbeck, Gijs H. Goossens, Jorg Hager, Jason C. G. Halford, Hans Hauner, David Jacobi, Chantal Julia, Dominique Langin, Andrea Natali, Martin Neovius, Jean Michel Oppert, Uberto Pagotto, Antonio L. Palmeira, Helen Roche, Mikael Rydén, André J. Scheen, Chantal Simon, Thorkild I. A. Sorensen, Luc Tappy, Hannele Yki-Järvinen, Olivier Ziegler, Martine Laville.
Lancet Diabetes Endocrinol. 2020 Oct 30:S2213-8587(20)30364-8. doi: 10.1016/S2213-8587(20)30364-8.
PubMed ID: 33137293


Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing – focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals’ responses to an intervention for obesity – ultimately leading to better patient care and improved obesity outcomes.