Gut 2017 Sep;66(9):1688-1696
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly...
Environ. Health Perspect. 2017 03;125(3):428-436
BACKGROUND: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, y...
Int J Obes (Lond) 2016 Dec;40(12):1823-1831
BACKGROUND: Adipose tissue fibrosis is a relatively new notion and its relationship with visceral obesity and cardiometabolic alte...
J. Clin. Endocrinol. Metab. 2016 Dec;101(12):4895-4903
CONTEXT: Adults with Prader-Willi syndrome (PWS) have an increased proportion of sc fat mass compared with body mass index (BMI)-m...
Ultrasound Med Biol 2016 Oct;42(10):2401-13
We describe a novel device called the AdipoScan that was adapted from the FibroScan to specifically assess shear wave speed (SWS) in human abdomina...
N. Engl. J. Med. 2016 Jul;375(3):240-6
Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hyp...
Placenta 2016 Aug;44:83-90
During pregnancy, the placenta ensures multiple functions, which are directly involved in the initiation, fetal growth and outcome of gestation. Th...
PLoS ONE 2016;11(7):e0159350
BACKGROUND: Visceral adipose tissue foam cells are increased in human obesity, and were implicated in adipose dysfunction and incr...
Arthritis Care Res (Hoboken) 2016 Jul;68(7):1036-42
OBJECTIVE: The mechanisms by which weight loss decreases serum uric acid (SUA) levels are poorly known. We aimed to investigate th...
J. Clin. Endocrinol. Metab. 2016 Jun;101(6):2578-87
CONTEXT: Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue ass...
BMJ Open Gastroenterol 2016;3(1):e000075
BACKGROUND: Type-2 diabetes mellitus (T2DM) is a risk factor for progressive non-alcoholic fatty liver disease (NAFLD). Drugs comm...
Sci Rep 2016 Apr;6:24618
Obesity is associated with local tissue hypoxia and elevated hypoxia-inducible factor 1 alpha (HIF-1α) in metabolic tissues. Prolyl hydroxylases (...
Obes Surg 2016 Apr;26(4):785-96
BACKGROUND: Roux-en-Y gastric bypass (GBP) and sleeve gastrectomy (SG) have increased dramatically, potentially increasing the pre...
PLoS ONE 2016;11(2):e0149588
BACKGROUND: The number of morbidly obese patients undergoing bariatric surgery (BS) has increased dramatically in recent years. Th...
Gut 2016 Mar;65(3):426-36
OBJECTIVE: Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut...
FASEB J. 2016 Jan;30(1):241-51
In mice, nutritional supplementation with the trans-10,cis-12 isomer of linoleic acid (t10,c12-CLA) promotes lipoatrophy, hyperinsulinemia, and mac...
J. Clin. Endocrinol. Metab. 2016 Jan;101(1):293-304
CONTEXT: Extracellular matrix (ECM) in sc adipose tissue (scAT) undergoes pathological remodeling during obesity. However, its evo...
Cell Metab. 2015 Dec;22(6):1045-58
Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-infl...
Endocrinology 2015 Nov;156(11):4047-58
Prior studies demonstrated increased plasma IgE in diabetic patients, but the direct participation of IgE in diabetes or obesity remains unknown. T...
PLoS ONE 2015;10(10):e0138880
BACKGROUND AND OBJECTIVES: Identification of new targets for metabolic diseases treatment or prevention is required. In this conte...